Exposure to pesticide mixtures and DNA damage among rice field workers Academic Article

abstract

  • This study describes the use of pesticides mixtures and their potential association with comet assay results in 223 rice field workers in Colombia. Thirty-one pesticides were quantified in blood, serum, and urine (15 organochlorines, 10 organophosphorus, 5 carbamates, and ethylenethiourea), and the comet assay was performed. Twenty-four (77.42%) pesticides were present in the workers. The use of the maximum-likelihood factor analysis identified 8 different mixtures. Afterwards, robust regressions were used to explore associations between the factors identified and the comet assay. Two groups of mixtures-α-benzene hexachloride (α-BHC), hexachlorobenzene (HCB), and β-BHC (β: 1.21, 95% confidence interval [CI]: 0.33-2.10) and pirimiphos-methyl, malathion, bromophos-methyl, and bromophos-ethyl (β: 11.97, 95% CI: 2.34-21.60)-were associated with a higher percentage of DNA damage and comet tail length, respectively. The findings suggest that exposure to pesticides varies greatly among rice field workers.

publication date

  • 2016/1/2

edition

  • 71

keywords

  • Assays
  • Association reactions
  • Blood
  • Carbamates
  • Colombia
  • Comet Assay
  • Confidence Intervals
  • DNA
  • DNA Damage
  • Ethylenethiourea
  • Factor analysis
  • Health Personnel
  • Hexachlorobenzene
  • Lindane
  • Malathion
  • Maximum likelihood
  • Oryza
  • Pesticides
  • Serum
  • Statistical Factor Analysis
  • Urine
  • assay
  • benzene
  • beta-hexachlorocyclohexane
  • blood
  • bromophos
  • carbamate (ester)
  • comet
  • confidence interval
  • damage
  • ethyl bromophos
  • exposure
  • factor analysis
  • hexachlorobenzene
  • malathion
  • organochlorine
  • paddy field
  • pesticide
  • pirimiphos methyl
  • serum
  • urine

International Standard Serial Number (ISSN)

  • 1933-8244

number of pages

  • 7

start page

  • 3

end page

  • 9