Introduction: The human immunodeficiency virus affects the lives of people especially regarding self-care, work and leisure time, factors that compromise the exercise of social participation. Objective: To describe the occupational performance of 29 patients living with HIV and AIDS assisted by the B24 program in a hospital in Bogotá-Colombia. Method: Descriptive and exploratory study on patterns of performance, occupational roles and independence in instrumental activities of daily living (IADL). An interview was conducted and an occupationalquestionnaire, the Lawton and Brody index, was used. Data were processed in SPSS and frequency analysis was performed. Results: Participants were 53 years old in average, 82.8% were men and 48.3% had higher education. They work an average of 2 hours a day and spend 11 hours a day with daily activities, and almost 5 or 6 hours with leisure and rest. The most significant roles are friend and family member, and the least significant, member of religious groups. Among participants, 65.5% are independent to develop IADL, 31% need help for some activities and 3.4% is dependent. Signs and symptoms of HIV and opportunistic infections make it difficult to assume roles, including work activities. Conclusion: Cobra value demonstrates the meaning of occupational transition for this group and its future perspective to implement programs that may foster the importance of their social and family participation.