Usos terapéuticos potenciales de los antagonistas opioides: Fisiopatología y evidencia preclínica Academic Article

abstract

  • Opioid system, which involved endogenous opioid peptides and their receptors (Miu, Kappa, delta and ORL), has a main role in the physiology of several systems. At the same time, there is cumulating evidence in the role of the opioid system in the physiopathology of several disorders in the central nervous, endocrine and immunological system. The modulation of the opioid system using nonspecific antagonists may have a therapeutic role in the symptomatic management of several diseases, as well as, in the emergency management of opioid analgesic overdose, opioid dependence and to reduce the drug side effects of the opioid agonists used in chronic pain. This paper aims to review the pharmacology of specific and nonspecific opioid antagonists, and update on possible new indications and therapeutic uses of such antagonists.

publication date

  • 2015/1/1

edition

  • 44

keywords

  • Chronic Pain
  • Disease Management
  • Drug-Related Side Effects and Adverse Reactions
  • Emergencies
  • Endocrine System
  • Narcotic Antagonists
  • Opioid Analgesics
  • Opioid Peptides
  • Peptide Receptors
  • Pharmacology
  • Therapeutic Uses
  • Therapeutics

International Standard Serial Number (ISSN)

  • 0034-7418

start page

  • 322

end page

  • 358