Introduction: The hypovitaminosis D is a recent risk factor in multiple sclerosis, optic neuromyelitis and spectrum of optic neuromyelitis, since it has been associated with the development and progression of these diseases. The objective to determine the prevalence of vitamin D deficiency in multiple sclerosis and optic neuromyelitis and its relationship with the clinical. Materials and Methods: Observational cross-sectional study, in which all patients older than 18 years with a diagnosis of Multiple Sclerosis with crteria of Mcdonald, optic neuromyelitis and optic neuromyelitis spectrum were enrolled, attending 3 centers of hospitalization and/or neurology consultation in Bogotá, between January 2014 to December 2016. Outcome: It was found that 71% of patients with these diseases had vitamin D deficiency, with 26. 8 ± 6. 1 ng / ml. No significant difference was found between hypovitaminosis and time (years) with demyelinating disease (p = 0. 55) or disease severity as determined by EDSS score (p = 0. 34), as well as factors that may influence its Prevalence (time of exposure, sunscreen and skin type). Conclusion: Patients with multiple sclerosis and optic neuromyelitis in Bogotá have vitamin D deficits, however, we did not find any relation with the clinical variables of the disease.
