Through this work seeks to reveal the key to organizational success based on leadership, quality of life and well-being. On the one hand addresses leadership in all their dimensions, the welfare as a fundamental pillar for the efficiency of an organization and the quality of life in the development of enterprise human talent.On the other hand shows the close relationship between these three great concepts to transcend from theory to implementation, and in this way provide a series of keys for those professionals who want to project the company to a higher level in a competitive scenario in a globalized world.