Factores asociados a infecciones en pacientes con artritis reumatoide tratados con abatacept subcutáneo atendidos en un centro de reumatología en Bogotá, Colombia
Thesis
INTRODUCTION: The aim of treatment for rheumatoid arthritis is to decrease the activity of the disease by modulating the immune system, with infections being one of the common adverse effects. Abatacept has immunomodulatory effect by inhibiting the co-stimulation of T lymphocytes reducing the inflammatory activity. OBJECTIVE: To determine the factors associated with the presentation of infections in patients with rheumatoid arthritis treated with subcutaneous abatacept. METHODS: Cross-sectional analytical study. The sociodemographic clinical and paraclinical characteristics of the patients were established. Statistical analysis determined those that were related to the presentation of infections. RESULTS: We included 59 (83. 09%) women and 12 (16. 90%) men with a mean age of 50. 92 years (SD 13. 50). 47 (66. 19%) had at least 1 infection report. Having received more than one antiTNF is associated with a lower number of reports per patient (p = 0. 046). The relationship between the number of previous antiTNFs and the presentation of infections (p = 0. 047) and the number of reported events (p = 0. 011) is independent of the sex and age of the patient. During the first 5 months of treatment there is a greater likelihood of recurrent infections (Spearman = -0. 42). CONCLUSIONS: Before initiating treatment with abatacept, history of previous treatment with antiTNF for rheumatoid arthritis should be considered, a close follow-up should be considered during the first 5 months. It’s necessary to carry out population studies with probabilistic sampling that explore factors that allow the construction of risk profiles for infections.
