Variaciones fisiológicas presentadas con la lentificación electroencefalográfica durante la hiperventilación en voluntarios sanos, Fundación Cardioinfantil
Thesis
Introduction: Electroencephalographic slowdown are delta and theta waves that can be present in the electroencephalogram (EEG) before an activation method such as hyperventilation (HV), a percentage of the healthy population presents this electroencephalographic pattern and could be indicative of a pathology of the central nervous system if it presents asymmetrically when comparing both cerebral hemispheres. The etiological mechanisms of this phenomenon have not been fully elucidated despite the proposition of various hypotheses. Objective: To determine if there is a change in the selected variables after presenting electroencephalographic slowing when performed in healthy volunteers. Materials and methods: A HV process was performed in 19 healthy adult subjects, measuring physiological variables such as PCO2, PO2, SaO2, pH, HCO3, base excess (BE), glycemia, blood pressure, estimation of cerebral blood flow velocity. (FSC) and pulsatility index (PI) in the middle cerebral artery (MCA), as well as electrolytes and frequency measured in Hz in the electroencephalogram (EEG); These variables were measured before starting the HV and after finishing it, an analysis was performed using the mean difference. Results: the sample consisted of 19 volunteer participants during the year 2022, electroencephalographic slowing was obtained at one minute of HV, DS 5.58 (CI 4.25, 6.91) and at 5 minutes of HV, DS 1.89 (IC 0.81, 2.98), the variables Gasimetrics reflect the role of secondary hypocapnia and pH as the main changes after the analysis, but this is not the case with the other variables analyzed. Conclusion: This is a quasi-experimental pilot study with a before and after design compatible with previous findings that can be used to determine the expected normality parameters for a healthy population, and from there, the planning of more extensive studies with different neurological pathologies.
