Introduction. Occupational asthma is one of the first respiratory pathologies in the workplace, its diagnosis in many cases is late and difficult to establish, since it requires a clear etiology and be related to the work. There are biological molecules that play an important role in the development of pathology such as Ig E and Ig G immunocomplexes, cytokines, genetic markers and protein biomarkers, however, making a cause-effect relationship is difficult and its use is limited. Goals. Identify the Biomarkers involved in occupational asthma. Materials and methods. A literature review was carried out in the PubMed, EBSCOhost and Google Scholar databases, between 2009 and 2019, in English and Spanish languages, using the search terms Asthma, Occupational, Isocyanates, Occupational Exposure, Histocompatibility Antigens Class, Polymorphism, Genetic . Results A total of 20 articles were selected, identifying the main biomarkers involved in occupational asthma from the context of susceptibility and effect and in turn a grouping into categories from the genetic, immunological and protein point of view. Isocyanate was found as the causative agent primarily related to biomarkers involved in occupational asthma, however, other causative agents were also related. Conclusions The susceptibility biomarkers have the majority of studies in the literature covering human leukocyte antigen and genetic polymorphisms, within the biomarkers of effect there are several studies regarding immunoglobulins and cytokines, however, the information collected from proteins as ferritin and transferrin is scarce and only studies with isocyanates were found, which are considered as the substances mainly involved in occupational asthma.
