Background: Recent lifestyle trends make it unclear which factors are the most important in the development of overweight-obesity in school aged-children. Objective. Evaluate the impact of prenatal, perinatal and environmental factors on the development of overweight and obesity in a population of Bogotá children aged 5-10 years. Material and Methods. We conducted a case-control study unpaired, using a survey of 528 children, in which are identified the risk factors. We used chi-square test to evaluate the difference between normal children and overweight-obesity. Then we performed a logistic regression analysis were used for the evaluation of relevant factors. Odds ratio (OR) and confidence intervals (CI) of 95% were calculated. Results. A total of 528 children were recruited. We found significant differences in caloric intake (p < 0. 001). The maternal pre-pregnancy overweight was of 23. 2% in cases mothers and 16. 5% of controls mothers (p < 0. 001). There were no statistically significant differences with other factors. Logistic regression analysis showed significant intake of calories data p = 0. 002 (OR = 5. 27, 95% CI 1. 79 to 1. 54) and maternal weight p = 0. 005 (OR = 1. 03, 95% CI 1. 01 -1. 05). ROC curve was performed to calculate the predictive ability of the model and the area under the curve is 0. 64 (95% CI 0. 59 to 0. 69). Conclusions. A high calorie diet and maternal pre-pregnancy overweight were identified as risk factors for the development of overweight-obesity in school aged-children.