Evaluation of a Cryptococcal antigen Lateral Flow Assay in serum and cerebrospinal fluid for rapid diagnosis of cryptococcosis in Colombia Academic Article

abstract

  • A Lateral Flow Assay to detect cryptococcal antigen (CrAg® LFA) in serum and cerebrospinal fluid for the rapid diagnosis of cryptococcosis was evaluated. A retrospective validation was performed. Sensitivity and specificity of the CrAg® LFA was 100%. High concordance (kappa index=1.0) between Cryptococcal Antigen Latex Agglutination System (CALAS®) and CrAg® LFA was observed. CrAg® LFA showed higher analytical sensitivity for detecting low concentrations of cryptococcal antigen.

publication date

  • 2017/12/21

edition

  • 59

keywords

  • Agglutination
  • Antigens
  • Cerebrospinal Fluid
  • Colombia
  • Cryptococcosis
  • Latex
  • Sensitivity and Specificity
  • Serum

International Standard Serial Number (ISSN)

  • 0036-4665

start page

  • e76