Role of MYH9 and APOL1 in African and non-African populations with lupus nephritis Academic Article

abstract

  • Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by autoantibody production and organ damage. Lupus nephritis (LN) is one of the most severe manifestations of SLE. Multiple studies reported associations between renal diseases and variants in the non-muscle myosin heavy chain 9 (MYH9) and the neighboring apolipoprotein L 1 (APOL1) genes. We evaluated 167 variants spanning MYH9 for association with LN in a multiethnic sample. The two previously identified risk variants in APOL1 were also tested for association with LN in European-Americans (EAs) (N=579) and African-Americans (AAs) (N=407). Multiple peaks of association exceeding a Bonferroni corrected P-value of P

authors

publication date

  • 2012/4/1

keywords

  • African Americans
  • Apolipoproteins
  • Autoantibodies
  • Autoimmune Diseases
  • Genes
  • Kidney
  • Lupus Nephritis
  • Myosin Heavy Chains
  • Population
  • Systemic Lupus Erythematosus

International Standard Serial Number (ISSN)

  • 1466-4879

number of pages

  • 7

start page

  • 232

end page

  • 238