Prevalence of Classic and Non-Classic Antiphospholipid Antibodies in Multiple Sclerosis Academic Article


  • Israel Medical Association Journal


  • BACKGROUND: The association between antiphospholipid antibodies (aPL) and multiple sclerosis (MS) has been suggested previously, but prior studies provided contradicting findings.OBJECTIVES: To characterize the expression profile of eight classic and non-classic aPL in patients diagnosed with MS.METHODS: Using the BioPlex 2200 immunoassay, we measured the levels of serum immunoglobulin (Ig)M and IgG isotypes of three classic aPL and five non-classic aPL in 98 subjects with MS and 237 healthy controls.RESULTS: Three non-classic aPL were significantly more prevalent among MS patients in comparison to the control group. These antibodies included IgM and IgG against phosphatidylserine-β2GPI (PS-B2), IgG prothrombin complex (PT-PT) and IgM prothrombin (PT). The positive results according to Bonferroni correction are PS-B2 IgG and PT-PT IgG. The remaining aPL profiles did not differ significantly between the two groups.CONCLUSIONS: An association between certain non-classic aPL and MS has been established. The specific role of these autoantibodies in the pathogenesis of the condition remains uncertain.

publication date

  • 2015/9/1


  • 17


  • Antibodies
  • Antiphospholipid Antibodies
  • Autoantibodies
  • Control Groups
  • Immunoassay
  • Immunoglobulin G
  • Immunoglobulin M
  • Multiple Sclerosis
  • Phosphatidylserines
  • Prothrombin
  • Serum
  • bioplex

International Standard Serial Number (ISSN)

  • 1565-1088

number of pages

  • 4

start page

  • 559

end page

  • 62