Hepatitis B virus infection and vaccine-induced immunity in Madrid (Spain) Academic Article


  • Gaceta Sanitaria


  • Objective: To estimate the prevalence of hepatitis B virus (HBV) infection and vaccine-induced immunity in the region of Madrid, and to analyze their evolution over time. Methods: An observational, analytical, cross-sectional study was carried out in the population aged 16-80 years between 2008 and 2009. This was the last of four seroprevalence surveys in the region of Madrid. The prevalence of HBV infection and vaccine-induced immunity was estimated using multivariate logistic models and were compared with the prevalences in the 1989, 1993 and 1999 surveys. Results: In the population aged 16-80 years, the prevalence of HBV infection was 11.0% (95% CI: 9.8-12.3) and that of chronic infection was 0.7% (95% CI: 0.5-1.1). The prevalence of vaccine-induced immunity in the population aged 16-20 years was 73.0% (95% CI: 70.0-76.0). Compared with previous surveys, there was a decrease in the prevalence of HBV infection. Conclusions: Based on the prevalence of chronic infection (<1%), Madrid is a region with low HBV endemicity. Preventive strategies against HBV should especially target the immigrant population.

publication date

  • 2014-1-1


  • 28


  • Cross-Sectional Studies
  • Health Services Needs and Demand
  • Hepatitis B
  • Hepatitis B Vaccines
  • Hepatitis B virus
  • Immunity
  • Infection
  • Logistic Models
  • Population
  • Seroepidemiologic Studies
  • Spain
  • Vaccines

International Standard Serial Number (ISSN)

  • 0213-9111

number of pages

  • 4

start page

  • 492

end page

  • 495