Autoimmune hepatitis - learning about your patients from their autoantibody profiles. Academic Article


  • Journal of Hepatology


  • Cholestatic liver disorders are caused by genetic defects, mechanical aberrations, toxins, or dysregulations in the immune system that damage the bile ducts and cause accumulation of bile and liver tissue damage. They have common clinical manifestations and pathogenic features that include the responses of cholangiocytes and hepatocytes to injury. We review the features of bile acid transport, tissue repair and regulation, apoptosis, vascular supply, immune regulation, and cholangiocytes that are associated with cholestatic liver disorders. We now have a greater understanding of the physiology of cholangiocytes at the cellular and molecular levels, as well as genetic factors, repair pathways, and autoimmunity mechanisms involved in the pathogenesis of disease. These discoveries will hopefully lead to new therapeutic approaches for patients with cholestatic liver disease.


publication date

  • 2014-6-7


  • 12


  • Apoptosis
  • Autoantibodies
  • Autoimmune Hepatitis
  • Autoimmunity
  • Bile
  • Bile Acids and Salts
  • Bile Ducts
  • Blood Vessels
  • Hepatocytes
  • Immune System
  • Inborn Genetic Diseases
  • Learning
  • Liver
  • Liver Diseases
  • Therapeutics
  • Wounds and Injuries

International Standard Serial Number (ISSN)

  • 0168-8278

number of pages

  • 6

start page

  • 1299

end page

  • 1304