High-Resolution Molecular Typing of Trypanosoma cruzi in 2 Large Outbreaks of Acute Chagas Disease in Colombia Academic Article

journal

  • Journal of Infectious Diseases

abstract

  • © 2016 The Author.Oral transmission of Trypanosoma cruzi has gained relevance because of its association with high morbidity and lethality rates. This transmission route is responsible for maintaining the infection of the parasite in sylvatic cycles, and human cases have been associated mainly with the consumption of food contaminated with triatomine feces or didelphid secretions. Several ecological changes allow the intrusion of sylvatic reservoirs and triatomines to the domestic environments with subsequent food contamination. Here, high-resolution molecular tools were used to detect and genotype T. cruzi across humans, reservoirs, and insect vectors in 2 acute outbreaks of presumptive oral transmission in eastern Colombia.
  • La transmisión oral de Trypanosoma cruzi ha ganado relevancia por su asociación con altas tasas de morbilidad y mortalidad. Esta vía de transmisión es la responsable de mantener la infección del parásito en los ciclos selváticos, y los casos humanos se han asociado principalmente con el consumo de alimentos contaminados con heces de triatomina o secreciones de didelphid. Varios cambios ecológicos permiten la intrusión de reservorios selváticos y triatomines en los ambientes domésticos con la consiguiente contaminación de los alimentos. Aquí se utilizaron herramientas moleculares de alta resolución para detectar y genotipo T. cruzi en humanos, reservorios e insectos vectores en 2 brotes agudos de presunta transmisión oral en el este de Colombia.

publication date

  • 2016/10/15

edition

  • 214

keywords

  • Acute Disease
  • Chagas Disease
  • Colombia
  • Disease Outbreaks
  • Feces
  • Food
  • Food Contamination
  • Genotype
  • Insect Vectors
  • Molecular Typing
  • Morbidity
  • Parasitic Diseases
  • Trypanosoma cruzi

International Standard Serial Number (ISSN)

  • 0022-1899

number of pages

  • 3

start page

  • 1252

end page

  • 1255