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  2. Edwin Alexander Rodríguez López
Edwin Alexander Rodríguez López
  • alexander.rodriguezl@urosario.edu.co

Edwin Alexander Rodríguez López

  • Profesor principal de carrera, Escuela de Medicina y Ciencias de la Salud , Universidad del Rosario - 2005
  • Investigador, Semillero de Investigación: BioTecnología aplicada a Medicina (BiTeM) , Grupo de Investigación Vida e Inteligencia Artificial - GIVIA - 2000

Áreas de investigación

  • Biochemistry
  • Bioinformatics
  • Biología celular
  • Biotechnology
  • Molecular biology
  • Perfil
  • Formación Académica
  • Publicaciones

Perfil

Perfil Profesional

  • Professor in School of Medicine and Health Sciences -Universidad del Rosario. PhD in Biochemistry and Biotechnology from the University of Ghent (Belgium) and PhD in Biological Sciences from the Pontificia Universidad Javeriana; with more than 14 years of experience in university education and scientific research, developing biotechnology projects in health. Director of more than 30 undergraduate and graduate theses. Visiting researcher at the National Institutes of Health (NIH). Co-founder and CTO of the biotechnology startup DOGMA BIOTECH (2023). Winner of the Biennial Awards for best research work in health (2019) and in Innovation (2023) from the Pontificia Universidad Javeriana. Currently I have two patents in Biotechnology.
  • Formación Académica

    Formación Académica Complementaria

  • 2025, Taller Bibliografías para Curso Fecha 1, Desarrollo profesoral-Universidad del Rosario
  • Publicaciones

    Publicaciones

  • artículos académico

    • Reactivation of Human X-Linked Gene and Stable X-Chromosome Inactivation Observed in Generation and Differentiation of iPSCs from a Female Patient with HNRNPH2 Mutation
      2025
    • Generation of an induced pluripotent stem cell line (TRNDi042-A) from a Mucopolysaccharidosis type IIIB patient with homozygous p. R626X (c. 1876C > T) mutation in the NAGLU gene
      2024
    • Identification of Orthosteric and Allosteric Pharmacological Chaperones for Mucopolysaccharidosis Type IIIB
      2024
    • Novel human recombinant N-acetylgalactosamine-6-sulfate sulfatase produced in a glyco-engineered Escherichia coli strain
      2024
    • Metabolic impact of infant formulas in young infants. An outlook from the urine metabolome
      2022
    • Engineering a heterologously expressed fructosyltransferase from Aspergillus oryzae N74 in Komagataella phaffii (Pichia pastoris) for kestose production
      2022
    • Effect of two preservation methods on the viability and enzyme production of a recombinant Komagataella phaffii (Pichia pastoris) strain
      2022
    • The prevalence of Chlamydia psittaci in confiscated Psittacidae in Colombia
      2022
    • 1H-nuclear magnetic resonance analysis of urine as diagnostic tool for organic acidemias and aminoacidopathies
      2021
    • Use of a neuron-glia genome-scale metabolic reconstruction to model the metabolic consequences of the Arylsulphatase a deficiency through a systems biology approach
      2021
    • Human recombinant lysosomal β-Hexosaminidases produced in Pichia pastoris efficiently reduced lipid accumulation in Tay-Sachs fibroblasts
      2020
    • Bromocriptine as a Novel Pharmacological Chaperone for Mucopolysaccharidosis IV A
      2020
    • Advances in the development of pharmacological chaperones for the mucopolysaccharidoses
      2020
    • Media improvement for 10 L bioreactor production of rPOXA 1B laccase by P. pastoris
      2019
    • Characterization of Human Recombinant N-Acetylgalactosamine-6-Sulfate Sulfatase Produced in Pichia pastoris as Potential Enzyme for Mucopolysaccharidosis IVA Treatment
      2019
    • Identification of Ezetimibe and Pranlukast as Pharmacological Chaperones for the Treatment of the Rare Disease Mucopolysaccharidosis Type IVA
      2019
    • Identification of the iduronate-2-sulfatase proteome in wild-type mouse brain
      2019
    • Gain-Scheduled Oxygen Concentration Control System for a Bioreactor
      2018
    • Neural stem cells for disease modeling and evaluation of therapeutics for Tay-Sachs disease
      2018
    • Production and characterization of a human lysosomal recombinant iduronate-2-sulfatase produced in Pichia pastoris
      2018
    • Research, diagnosis and education in inborn errors of metabolism in Colombia
      2018
    • In Silico Analysis of the Structure of Fungal Fructooligosaccharides-Synthesizing Enzymes
      2018
    • Improvement in the production of the human recombinant enzyme N-acetylgalactosamine-6-sulfatase (rhGALNS) in Escherichia coli using synthetic biology approaches
      2017
    • Anaerobic sulfatase maturase AslB from Escherichia coli activates human recombinant iduronate-2-sulfate sulfatase (IDS) and N-acetylgalactosamine-6-sulfate sulfatase (GALNS)
      2017
    • Production of human recombinant phenylalanine hydroxylase in Lactobacillus plantarum for gastrointestinal delivery
      2017
    • Understanding the metabolic consequences of human Arylsulfatase a deficiency through a computational systems biology study
      2017
    • Plackett-burman design for rGILCC1 laccase activity enhancement in pichia pastoris
      2017
    • Production of Recombinant Trichoderma reesei Cellobiohydrolase II in a New Expression System Based on Wickerhamomyces anomalus
      2017
    • Recombinant human N-acetylgalactosamine-6-sulfate sulfatase (GALNS) produced in the methylotrophic yeast Pichia pastoris
      2016
    • Systems biology study of mucopolysaccharidosis using a human metabolic reconstruction network
      2016
    • Characterization of recombinant human lysosomal beta-hexosaminidases produced in the methylotrophic yeast Pichia pastoris
      2016
    • Human recombinant lysosomal enzymes produced in microorganisms
      2015
    • Impact of enzyme replacement therapy and hematopoietic stem cell transplantation in patients with morquio a syndrome
      2015
    • Computational analysis of human N-acetylgalactosamine-6-sulfate sulfatase enzyme
      2014
    • Characterization of a new bacteriocin from Lactobacillus plantarum LE5 and LE27 isolated from ensiled corn
      2014
    • Production of Trametes pubescens Laccase under Submerged and Semi-Solid Culture Conditions on Agro-Industrial Wastes
      2013
    • Effect of culture conditions and signal peptide on production of human recombinant N-acetylgalactosamine-6-sulfate sulfatase in Escherichia coli BL21
      2013
    • Computational analysis of the fructosyltransferase enzymes in plants, fungi and bacteria
      2011
    • Development of a sandwich enzyme linked immunosorbent assay (ELISA) for the quantification of iduronate-2-sulfate sulfatase
      2011
    • Evaluation of toxicity and degradation of a chlorophenol mixture by the laccase produced by Trametes pubescens
      2011
  • prensa y medios

    • Three clues from De la Espriella's appointments about what his administration will be like
      2026
    • Colombia’s Right-Wing Offensive and the Politics of Order
      2026
    • This is how Ricardo Roa, Petro's key man at Ecopetrol, built his power
      2026
    • Findings from Pontificia University Javeriana Yields New Data on Mucopolysaccharidoses (Identification of Orthosteric and Allosteric Pharmacological Chaperones for Mucopolysaccharidosis Type Iiib)
      2024
    • New Science and Technology Study Findings Recently Were Published by Researchers at Pontifical University Javeriana (Novel human recombinant N-acetylgalactosamine-6-sulfate sulfatase produced in a glyco-engineered Escherichia coli strain)
      2024
    • Season of Achievements: 2023–24 Fellowships, Scholarships, and Awards
      2024
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