Introduction Uric acid has been described as a possible risk marker for the development of preeclampsia. However, so far there is no solid evidence to support it. The objective of this study is to synthesize the available literature that allows us to know the usefulness of uric acid as a screening tool for preeclampsia. Methodology Systematic review of the literature of primary studies that analyze serum uric acid levels in the first and second trimesters of pregnancy with the development of preeclampsia. Pubmed (n: 639) and cross-reference search. Results Four studies were included (1 case-control and 3 cohorts) with a total of 11,603 pregnant women and 575 cases of pre-eclampsia. In all the studies, a higher mean uric acid was found in pregnant women who developed pre-eclampsia and all the studies that presented adjusted OR (n: 3) showed higher odds in those women with elevated uric acid levels (OR 1.8 to 2.0). Conclusions Elevated uric acid in the first and second trimesters is related to the presence of preeclampsia, which is why it can be considered as a screening tool in this pathology. The various studies give an account of the elevation of the levels and the subsequent hypertensive state, as well as its relationship with the pathophysiology of the disease. More evidence is required to use increased uric acid levels as an early marker of preeclampsia globally.
publication date
February 23, 2021 1:25 AM
Research
keywords
Analysis of serum uric acid levels during pregnancy
Elevated uric acid correlation and hypertensive state
