Introduction: Pre-eclampsia is a disorder characterized by hypertension and proteinuria due to kidney injury which is diagnosed by collecting urine for 24 hours and being positive ≥300mg/dl, the importance of the study lies in determining the diagnostic yield of proteinuria in 12 hours for a value of ≥150mg/dl. Objective: To evaluate the diagnostic performance of renal lesion in hypertensive pregnant patients with proteinuria in 12 hours ≥150mg/dl and to compare with proteinuria in 24 hours ≥300mg/dl. Method: Diagnostic, prospective study in 105 pregnant women with hypertension to be classified, admitted to the Bogotá Bogotá University Clinic, during the period of 01/11/2017-31/03/018. The diagnostic performance was determined by sensitivity, specificity, PPV, NPV, likelihood ratio and prediction with ROC. Results: The cohort was composed of 105 pregnant women with hypertensive >20 weeks, the median age was 31.8 6.4 years. The optimal cut-off point found for proteinuria at 12 hours was ≥145mg/dl, showing sensitivity of 81.08% (95% CI 67.11-95.05%), 91.18% specificity (95% CI 83,7-98.6%), PPV 83.3% (69.6-96.9%) NPV 89.8% (82.01-97.7%) and LR + 9.19 (4.21-20,04), LR- 0.21(0.11-0.41), predictive area under the curve 95.5% (95% CI: 91.9-99.2% p<0.001). A direct and strong correlation was found between the numerical values of proteinuria at 12 and 24 hours (rs=0.854, p<0.001). Conclusion: The optimal cut-off point ≥145mg/dl for proteinuria during 12 hours has a high diagnostic yield and is very useful given its high predictive value of renal injury in hypertensive pregnant women and we recommend its application to obtain a faster diagnosis.
