Substance use disorders represent a major challenge to mental health and quality of life, especially in Colombia, a country that faces drug production and consumption. While policies are in place that address mental health issues related to substance use, barriers to effective treatment and improved quality of life remain. Objective: This study aimed to assess the quality of life of people aged 18 to 35 years diagnosed with substance use disorders using the WHOQoL-BREF questionnaire. Methods: A cross-sectional study that included 50 patients between 18-35 years of age, diagnosed with substance use disorders, recruited from the outpatient services of the Integrated Subnetwork of Health Services South E.S.E in Bogotá, Colombia, in 2024. Socioeconomic and clinical data were collected, along with WHOQoL-BREF scores. Principal component analysis identified variables with the greatest impact on quality of life, and a decision tree analysis identified potential intervention targets. Results: The sample (n= 50) had a mean age of 27.4 years (SD=5.36), composed mostly of men (84%) from low socioeconomic backgrounds. The almost daily consumption of tobacco, cannabis and cocaine was frequent, generating associated problems, interference in daily activities and family concern. Factors such as satisfaction with relationships, health problems, family preoccupation with consumption and interference with activities impacted quality of life. Conclusion: These findings identify specific risk factors that affect quality of life in people with substance use disorders. In addition, there are specific areas where health services, prevention strategies, and treatment approaches can be adapted to improve the quality of life for people with substance use disorders.
