Trasplante hepático pediátrico con donante vivo en Colombia análisis desde la bioética y el bioderecho Thesis

short description

  • Master's thesis

Thesis author

  • Vanegas - Forero, Laura Camila

abstract

  • Context: In 2022, 82.27% of pediatric liver transplants in Colombia were performed using living donors. This workshop proposes to identify a distinct focus within the donation and transplant network concerning the pediatric population in order to assess whether the collected information in the country adequately safeguards the best interests of children and adolescents, ensures timely access to transplantation, and facilitates the appropriate allocation of resources to pediatric population. Additionally, both living donor and receptors are patients for this reason it is necessary to evaluate the potential risks taking into account the principles of beneficence and no maleficence Methodology An argument essay was developed based on researching the annual and ejective reports of donation and transplant network since 2019 to 2022, as well as the official documents of “Instituto Nacional de Salud”. In addition, a literature revision was conducted on platforms such as as sciencedirect, pubmed, scielo, google scholar since 2017 to 2023 and official websites of country ́s governments with transplant leaderships roles were also consulted in order to verify mortality and morbidity international rates. Furthermore, colombian legal context review was done, about transplant practices in relationship with the best interest of the children and adolescents. Results The reports from ̈Instituto Nacional de Salud ̈ report specific and detailed statistics on pediatric liver transplant since 2019 and these liver transplants were made principle with living donors. The minimal age of transplant was 1 month. Additionally, the organ donation rate in Colombia has declined and now falls below that of leading countries in donation and transplantation. (13–16) Literature review generally indicates mortality rate in living donor in hepatic transplant from 10% to 67%. However, a systematic review suggests that mortality may be estimated in 0.2%, with even lower rates when it is used left lobe (0.05-0.21%). Over the past six years, several retrospective studies, notably the largest in the eastern region, have demonstrated recipient survival rates at 10 years exceeding 90%, with the lowest reported rate being 52.2%. Conclusion The absence of statistics regarding the mean etiology in pediatric liver transplant, as well the lack of differential characterization go against to the Constitution and constitutional principles due to the absence of established protocols in pediatric population violates their rights. It is essential to approach this lack of information in order to guarantee the correct and respectful attention in pediatric population who may need liver transplant or other therapeutic alternative.

publication date

  • March 21, 2024 9:09 PM

keywords

  • Beneficence
  • Liver transplant
  • Living donor
  • Outcomes
  • Pediatric

Document Id

  • 7a67e34f-d86b-47ef-be27-a28f0a609209