Efectos en la función renal en población expuesta a mercurio: revisión de alcance Thesis

short description

  • Master's thesis

Thesis author

  • Restrepo Laverde, Lina Alexandra
  • Sarmiento Gamboa, Leidy Tatiana

external tutor

  • Trillos Peña, Carlos Enrique
  • Trillos, Carlos Enrique
  • Varona Uribe, Marcela Eugenia
  • Varona-Uribe, Marcela

abstract

  • Introduction: Mercury is a toxic metal, used by industry for labor and mining activities. Mercury wastes that enter the population indiscriminately have become a public health problem, given the alterations, it produces at the level of the different organic systems. However, the relationship between mercury exposure and its effects on the kidney is not clear. Objective: To characterize the alterations in kidney function parameters and the factors related to mercury exposure in the occupational and environmentally exposed population. Methodology: Scope review, primary original studies from the Science Direct, Pubmed, and SciELO databases in English and Spanish from 2000 to 2019 were analyzed. Socio-demographic characteristics, factors related to mercury exposure, and diagnostic tests to evaluate kidney damage. 480 articles were initially identified in databases. Results: A total of 34 articles were selected for full-read analysis. Thirteen studies were found in the occupational population exposed to mercury; renal function indicators such as albumin (P = 0.03), IgG (P <0.01), and α 1 -microglobulin (P = 0.04) in urine were significantly elevated in the miners. Nine publications were found with exposure to mercury in children, reporting an association between levels of mercury and albumin, β2MG, NAG, GST-α, and GST-π. Finally, 12 studies in environmentally exposed populations report that the concentration of mercury in blood has been reduced, without exceeding permissible limits (3.08 μg / L).

publication date

  • January 29, 2021 5:55 AM

keywords

  • Chemical occupational hazard
  • Correlation renal insufficiency exposure to mercury
  • Elemental Hg levels in miners
  • Kidney disease from mercury poisoning
  • Nephrotoxicity
  • Occupational risk in the mining industry

Document Id

  • 7f899c5e-4aa7-49cf-b953-d92cdd5d57ae