Introduction: Liver disease is a common cause of mortality in adults and transplantation is an alternative treatment that improves survival and quality of life. However, in the long term, complications such as chronic kidney disease that constitute morbidity and mortality can occur and, if modified early, the appearance of renal complications could be prevented. Methods: Historical cohort. Results: 421 patients were included, with a glomerular filtration rate of less than 60 thousand / min / 1.73 m2 up to 13 years post-transplant. The history of diabetes and hypertension and acute kidney injury in the post-transplant are the main factors associated with the rise in creatinine over time. Edematous ascitic decompensation also shows a smaller relationship. No relationship was found with the use of anticalcineurinics, hepatitis C infection, or other perioperative or paraclinical characteristics. Discussion: The prevalence, as well as the time of rise of creatinine in this cohort is lower than that reported in the literature in patients with liver transplantation, which suggests that early interventions for pharmacological adjustment and control of comorbidities translate into apparent less deterioration of renal function in these patients. Conclusion: The deterioration of the renal function is related to antecedents such as arterial hypertension, diabetes, ascites and acute kidney injury in post-transplant. There was no relationship with anticalcineurinics suggesting that the institutional protocol with early immunosuppression adjustments delay the rise of creatinine and the development of chronic kidney disease.
