Immune thrombocytopenia (IT) is a condition that in the vast majority of cases has an autoimmune character, it is necessary to differentiate between primary IT and secondary IT. In Latin America and especially in Colombia there are no recent studies on thrombocytopenia purpura. Methodology: An observational, cross-sectional study with an analytical component was presented in pediatric patients with thrombocytopenic purpura, treated during the period from June 1, 2014 to June 1, 2018 at the Children's Cardio Foundation. Results: 2106 medical records were reviewed, presenting diagnostic codes of ICD 10; D473 essential (hemorrhagic) thrombocytopenia, D692 Other non-thrombocytopenic purpura, D693 Idiopathic thrombocytopenic purpura. Finally 170 stories met the inclusion criteria, primary thrombocytopenia was found in 68 cases (40%), and in 102 cases (60%) corresponded to thrombocytopenia of secondary origin, including autoimmune, drug, neoplastic causes, Infectious, viral, hematological and by vaccination. Among the causes of secondary origin the infectious cause is the most frequent being of viral etiology the most found in 18 cases (10.6%), of autoimmune origin, SLE was the entity that appeared most frequently. Conclusion: The clinical characteristics of patients with thrombocytopenia were described, finding that, of the causes of thrombocytopenia, those of secondary origin are more frequent, and within this category, those of viral origin are the most common, followed by autoimmune and neoplastic causes.