Introduction: Non-alcoholic steatohepatitis (NASH), is an underdiagnosed and underestimated disease, usually asymptomatic, with documented association with obesity and overweight, which increase the progression to hepatic fibrosis, so it is necessary to understand NASH as a non-isolated liver disease. , which is part of a severe metabolic dysfunction that can progress to cirrhosis and liver cancer, being currently one of the main causes of liver transplantation, being associated with an increased risk of cardiovascular morbidity and mortality. Objective: To determine the relationship between weight variation in one year and levels of transaminases, lipids and insulinemia in adults with nonalcoholic steatohepatitis with recommendation of weight reduction. Methodology: Retrospective cohort of adult patients with non-alcoholic steatohepatitis registered in an anonymized database of a center of liver diseases in Colombia, who entered between 2011 and 2016, with a minimum follow-up of 1 year. Demographic characterization of the group and clinical and metabolic variables will be carried out, with exploration of the relationship between transaminase values as inflammatory indicators and the behavior of weight, age, gender, clinical and metabolic factors. Results: The relationship between weight variation in one year and levels of transaminases, lipids and insulinemia in adult NASH was confirmed, presenting an effect on AST transaminase levels (p 0,002 IC -0.5-0,1), but not ALT and GGT levels after 1 year of follow-up. There was also a correlation between the variation of weight and the variation of insulin levels (p <0,05 IC 0,2-0,4).
