Objective: To evaluate the association between handgrip strength and ideal cardiovascular health in Colombian children and adolescents. Study design: During the 2014-2015 school years, we examined a crosssectional component of the FUPRECOL study. Participants included 1,199 (n=627 boys) youths from Bogota (Colombia). Handgrip strength was measured with a standard adjustable hand held dynamometer and expressed relative to body mass (HG/body mass) and as absolute values in kilograms. Ideal cardiovascular health, as defined by the American Heart Association, was determined as meeting ideal levels of the following components: four behaviours (smoking status, body mass index, cardiorespiratory fitness, and diet) and three factors (total cholesterol, blood pressure and glucose). Results: Higher levels of handgrip strength (both absolute and relative values) were associated with a higher frequency of ideal cardiovascular health metrics in both sexes (p for trend ≤0.001). Also, higher levels of handgrip strength were associated with a greater number of ideal health behaviours (p for trend <0.001 in both boys and girls), and with a higher number of ideal health factors in boys (p for trend <0.001). Finally, levels of handgrip strength were similar between ideal versus non-ideal glucose or total cholesterol groups in girls. Conclusions: Handgrip strength was strongly associated with ideal cardiovascular health in Colombian children and adolescents, and thus supports the relevance of early targeted interventions to promote strength adaptation and preservation as part of primordial prevention.