Background: The objective of this study was to describe at 120 months, the impact on a cohort of patients treated for excess weight in an endocrinology institution (ENDOCARE), receiving integrated interdisciplinary treatment (MMI) compared to a control group. Methodology: Retrospective descriptive study of a dynamic cohort of 62 patients in whom clinical and paraclinical metabolic parameters were assessed between 2006-2009. Results: At 120 months, in the integrated interdisciplinary group (MMI), the maximum weight decrease, and the maximum waist decrease were most frequently presented. Additionally, patients in this group had a decrease in the median BMI, there was a decrease in diastolic blood pressure to a greater extent and there was an increase in the levels of HDL high density lipoproteins. Conclusion: The MMI integrated multidisciplinary overweight treatment showed positive results; showing that persistent contact with the patient is important for adherence and long-term success.