Background: Hypoxic-ischemic encephalopathy (HIE) is an acute neurological dysfunction. The EHI affects 5/1000 term newborns worldwide. Mortality ranges from 25% to 85% with EHI. The treatment of moderate and severe EIH is therapeutic hypothermia. The literature in Colombia is limited on the management of HIE. Objective: The study described the clinical, paraclinical and demographic characteristics of patients with moderate to severe perinatal asphyxia with therapeutic hypothermia protocol in the FCI from January 2016 to July 2017. Methodology: Observational study of a cohort. Descriptive statistics were used to present the characteristics of the patients, as well as the frequency of fatal outcomes such as death and nonfatal outcome such as prolonged stay and prolonged intubation. Results: In the total of 64 patients, mortality was 6.25% (n = 4). 54% were male, 99% received advanced resuscitation maneuvers, the average age at the beginning of the protocol was 6 hours. The results of the mortality outcome were associated with: the age of admission to the protocol, alteration in coagulation, lactate, liver enzymes, cardiac enzymes and glycemia (P: 0.01). Non-fatal desence of prolonged stay was associated with excess base, renal function and ph (P: 0.01).Conclusion: The fatal decrease in death was associated with the age at onset of the hypothermia protocol, alteration of hepatic and cardiac enzymes, coagulation times, glycemia and lactate elevation. The non-fatal outcome of prolonged intubation was associated with impaired renal function, pH and excess base.