This investigation will seek to have the foreign policy interests that motivate the Brasilia-Tehran rapprochement given in trade and energy. While Caracas-Tehran interests are supporting their anti-imperialist discourse. The investigation was divided into four parts in order to deepen adequately of concepts, the theoretical framework used is based on the perspective of constructivism. First, explain Irans foreign policy. Secondly, and analyze the interests mentioned in Irans foreign policy toward Venezuela. Third, we analyze the foreign policy interests of Iran to Brazil. Finally, we determine the projections (future scenarios) of the bilateral relations between Iran and Venezuela and Iran and Brazil. Finally the conclusion of this investigation strengthen the analysis of Irans interests in South America in the field of bilateral relations with Venezuela and Brazil.