Introduction: Epilepsy represents a significant social burden which also affects inpatient costs, mainly in those with uncontrolled epilepsy. Objective: To determine the inpatient costs of patients with a history of epilepsy who are admitted to the emergency room for epileptic seizures. Materials and methods: Patients with a diagnosis of epilepsy who were admitted to the emergency room for epileptic seizures were included. The sample size was calculated by detecting the impact of nonadherence, taking an expected proportion of 30%, with 5% precision and a 95% confidence level and power, for a sample size of 313 patients. Results: The total sample was made up of 313 patients with an epilepsy diagnosis who were admitted to the emergency room between January 2017 and April 2018 for epileptic seizures. Of these, 47.0% had controlled epilepsy and 51.0% had uncontrolled epilepsy. Twenty-two percent of all the patients were diagnosed with drug resistance. The total direct cost amounted to $1,574,746,247 COP. Within this total cost, the greatest increase was influenced by the lack of antiseizure medication delivery by the health insurance company and interrupted treatment (voluntary or forgetting to take the doses). Conclusion: According to the proposed model, patients with a history of uncontrolled epilepsy are associated with increased total direct inpatient costs
