The purpose of research in the search for integral nutritional solutions for the comprehensive management of high-cost pathologies, in order to propose alternative solutions in the context of the General System of Social Security in Health of Colombia. To this end, it was developed in the phases, the first phase included a review of the literature on the trends of cost-effectiveness analysis of enteral nutrition technologies in hospitalized patients, and the second phase of partial economic evaluations, an evaluation of the total cost of the hospital nutritional care process in high-cost pathologies such as stomach, colon and rectal cancer, and an evaluation of the impact of enteral nutritional supplementation on the quality of life of hospitalized patients with chronic kidney disease. After approval by the Scientific Technical Committee of Méderi, organization in which the applied component of the present doctoral thesis was advanced and approval by the EuroQol Research Foundation for the use of instruments of its authorship, it was proceeded to the lifting and processing of data. This thesis confirms the importance of the management of the nutritional hospital care within the framework of the management of diseases, as an administrative and assistance procedure that provides methodologies and tools that help to understand the phenomenon of the durability of the hospital institutions, which It is currently facing crisis and financial situations that involve closures of organizations, affecting the health care of the population, mainly the most vulnerable, such as patients with high-cost pathologies.
