Background: Exogenous Ochronosis (OE) is an underdiagnosed and difficult to treat condition (1). The Q-switched (QS) laser is an alternative for the treatment of this disease (2).Objective: To describe the patient’s characteristics and the QS laser features and subsequent outcomes after the use of this type of laser in the treatment of exogenous ochronosis.Methods: We conducted a structured search in PubMed, Embase, PMC, Scielo, Elselvier, BMJ Case Reports, Journal of Medical Case Reports, Cases Journal and International Medical Case Reports Journal, from January 2000 to March 2016, exogenous ochronosis patients, between 18 to 70 years old, treated with laser QS. The articles were evaluated by the assessment tool validity and educational value of case reports described by Pierson (3).Results: 256 items found, after evaluation of the summary 63 articles were selected, 28 were duplicated, and 31 were excluded for not meeting inclusion criteria. 4 articles reporting 12 cases of patients with exogenous ochronosis diagnosed by histopathology and treated with laser QS were selected.Discussion: There is little experience with laser QS en OE. In clinical practice used for tattoos and dermal pigmentary diseases with satisfactory results. The dermal pigment OE and short laser pulse duration QS could be the mainstay of treatment for OE.Conclusion: The use of QS laser can be useful for the management of patients with OE, level of evidence 3 and grade of recommendation D. It is suggested to perform clinical studies with greater evidence.