Characterisation of the Plasmodium vivax Pv38 antigen Academic Article

abstract

  • This study describes the identification and characterisation of Pv38, based on the available genomic sequence of Plasmodium vivax and previous studies done with its Plasmodium falciparum homologue: Pf38. Pv38 is a 355 amino acid long peptide encoded by a single exon gene, for which orthologous genes have been identified in other Plasmodium species by bioinformatic approaches. As for Pf38, Pv38 was found to contain a s48/45 domain which is usually found in proteins displayed on gametocytes surface. The association of Pv38 with detergent-resistant membranes (DRMs), its expression in mature blood stages of the parasite (mainly schizonts) and the detection of its recombinant protein by sera from Aotus monkeys previously exposed to the parasite, were here assessed to further characterise this new antigen. © 2008 Elsevier Inc. All rights reserved.

publication date

  • 2008/11/14

keywords

  • Amino Acids
  • Antigens
  • Bioinformatics
  • Blood
  • Computational Biology
  • Detergents
  • Exons
  • Genes
  • Haplorhini
  • Membranes
  • Parasites
  • Peptides
  • Plasmodium
  • Plasmodium falciparum
  • Plasmodium vivax
  • Proteins
  • Recombinant Proteins
  • Schizonts
  • Serum

International Standard Serial Number (ISSN)

  • 0006-291X

number of pages

  • 5

start page

  • 326

end page

  • 330