Refined mapping of a quantitative trait locus on chromosome 1 responsible for mouse embryonic death Academic Article


  • PLoS One


  • Recurrent spontaneous abortion (RSA) is defined as the loss of three or more consecutive pregnancies during the first trimester of embryonic intrauterine development. This kind of human infertility is frequent among the general population since it affects 1 to 5% of women. In half of the cases the etiology remains unelucidated. In the present study, we used interspecific recombinant congenic mouse strains (IRCS) in the aim to identify genes responsible for embryonic lethality. Applying a cartographic approach using a genotype/phenotype association, we identified a minimal QTL region, of about 6 Mb on chromosome 1, responsible for a high rate of embryonic death (~30%). Genetic analysis suggests that the observed phenotype is linked to uterine dysfunction. Transcriptomic analysis of the uterine tissue revealed a preferential deregulation of genes of this region compared to the rest of the genome. Some genes from the QTL region are associated with VEGF signaling, mTOR signaling and ubiquitine/proteasome-protein degradation pathways. This work may contribute to elucidate the molecular basis of a multifactorial and complex human disorder as RSA. © 2012 Vatin et al.

publication date

  • 2012/8/16


  • Association reactions
  • Chromosomes
  • Chromosomes, Human, Pair 1
  • Congenic Mice
  • Degradation
  • Deregulation
  • Embryonic Development
  • First Pregnancy Trimester
  • Genes
  • Genetic Association Studies
  • Genome
  • Habitual Abortion
  • Infertility
  • Mortality
  • Phenotype
  • Population
  • Proteasome Endopeptidase Complex
  • Proteins
  • Proteolysis
  • Quantitative Trait Loci
  • Spontaneous Abortion
  • Tissue
  • Vascular Endothelial Growth Factor A
  • abortion (animals)
  • chromosomes
  • embryonic mortality
  • etiology
  • genes
  • genetic techniques and protocols
  • genome
  • genotype-phenotype correlation
  • human fertility
  • mice
  • phenotype
  • pregnancy
  • proteasome endopeptidase complex
  • protein degradation
  • quantitative trait loci
  • transcriptomics
  • uterine tissue

International Standard Serial Number (ISSN)

  • 1932-6203