Characterisation and comparative analysis of MHC-DPA1 exon 2 in the owl monkey (Aotus nancymaae) Academic Article

journal

  • Gene

abstract

  • The Aotus nancymaae (owl monkey) is an important animal model in biomedical research, particularly for the preclinical evaluation of vaccine candidates against Plasmodium falciparum and Plasmodium vivax, which require a precisely typed major histocompatibility complex. The exon 2 from A. nancymaae MHC-DPA1 gene was characterised in order to infer its allelic diversity and evolutionary history. Aona-DPA1 shows no polymorphism and is related to other primate DPA alleles (including Catarrhini and Platyrrhini), constituting an ancient trans-specific and strongly supported lineage with different variability and selective patterns when compared to other primate-MHC-DPA1 lineages. A. nancymaae monkeys have thus a smaller MHC-DP polymorphism than MHC-DQ or MHC-DR. © 2010 Elsevier B.V.

publication date

  • 2011/1/1

keywords

  • Alleles
  • Animal Models
  • Aotidae
  • Biomedical Research
  • Catarrhini
  • Exons
  • Genes
  • Haplorhini
  • History
  • Major Histocompatibility Complex
  • Plasmodium falciparum
  • Plasmodium vivax
  • Platyrrhini
  • Primates
  • Vaccines

International Standard Serial Number (ISSN)

  • 0378-1119

number of pages

  • 9

start page

  • 37

end page

  • 45