Genetic Diversity and Selection in Three Plasmodium vivax Merozoite Surface Protein 7 (Pvmsp-7) Genes in a Colombian Population Academic Article

journal

  • PLoS One

abstract

  • A completely effective vaccine for malaria (one of the major infectious diseases worldwide) is not yet available; different membrane proteins involved in parasite-host interactions have been proposed as candidates for designing it. It has been found that proteins encoded by the merozoite surface protein (msp)-7 multigene family are antibody targets in natural infection; the nucleotide diversity of three Pvmsp-7 genes was thus analyzed in a Colombian parasite population. By contrast with P. falciparum msp-7 loci and ancestral P. vivax msp-7 genes, specie-specific duplicates of the latter specie display high genetic variability, generated by single nucleotide polymorphisms, repeat regions, and recombination. At least three major allele types are present in Pvmsp-7C, Pvmsp-7H and Pvmsp-7I and positive selection seems to be operating on the central region of these msp-7 genes. Although this region has high genetic polymorphism, the C-terminus (Pfam domain ID: PF12948) is conserved and could be an important candidate when designing a subunit-based antimalarial vaccine. © 2012 Garzon-Ospina et al.

publication date

  • 2012/9/25

keywords

  • Alleles
  • Antibodies
  • Antimalarials
  • Communicable Diseases
  • Genes
  • Genetic Polymorphisms
  • Genetic Recombination
  • Genetic Selection
  • Host-Parasite Interactions
  • Infection
  • Malaria Vaccines
  • Membrane Proteins
  • Merozoites
  • Multigene Family
  • Nucleotides
  • Parasites
  • Plasmodium merozoite surface protein 7
  • Plasmodium vivax
  • Polymorphism
  • Population
  • Proteins
  • Single Nucleotide Polymorphism
  • Vaccines
  • alleles
  • antibodies
  • antimalarials
  • genes
  • genetic polymorphism
  • genetic variation
  • host-parasite relationships
  • infection
  • infectious diseases
  • loci
  • malaria vaccines
  • membrane proteins
  • merozoites
  • multigene family
  • nucleotides
  • parasites
  • proteins
  • single nucleotide polymorphism
  • surface proteins
  • vaccines

International Standard Serial Number (ISSN)

  • 1932-6203