Fine mapping of Xq28: Both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups Academic Article


  • Annals of the Rheumatic Diseases


  • Objectives: The Xq28 region containing IRAK1 and MECP2 has been identified as a risk locus for systemic lupus erythematosus (SLE) in previous genetic association studies. However, due to the strong linkage disequilibrium between IRAK1 and MECP2, it remains unclear which gene is affected by the underlying causal variant (s) conferring risk of SLE. Methods: We fine-mapped ≥136 SNPs in a ∼227 kb region on Xq28, containing IRAK1, MECP2 and seven adjacent genes (L1CAM, AVPR2, ARHGAP4, NAA10, RENBP HCFC1 and TMEM187), for association with SLE in 15 783 case-control subjects derived from four different ancestral groups. Results: Multiple SNPs showed strong association with SLE in European Americans, Asians and Hispanics at p


publication date

  • 2013/3/1


  • Asian Americans
  • Genes
  • Genetic Association Studies
  • Hispanic Americans
  • Linkage Disequilibrium
  • Neural Cell Adhesion Molecule L1
  • Single Nucleotide Polymorphism
  • Systemic Lupus Erythematosus

International Standard Serial Number (ISSN)

  • 0003-4967

number of pages

  • 8

start page

  • 437

end page

  • 444