Aging is a widespread biological process, with large natural diversity, it can assume different forms in tissues, organs, individuals and species, the nature of aging is stochastic and complex. However, aging is subject to regulation by evolutionary highly conserved pathways as IGF-1 or mTOR signaling. There are several interventions that extend life span in many organisms, they include environmental factors (caloric restriction, CR), genetic manipulations (dwarf mice, daf-2 mutations), and drug
