Specific β-Turns Precede PPIIL Structures Binding to Allele-Specific HLA-DRβ1* PBRs in Fully-Protective Malaria Vaccine Components Academic Article

abstract

  • The 3D structural analysis of 62 peptides derived from highly pathogenic Plasmodium falciparum malaria parasite proteins involved in host cell invasion led to finding a striking association between particular β-turn types located in the N-terminal peripheral flanking residue region (preceding the polyproline II left-handed structures fitting into the HLA-DRβ* allele family) and modified immune protection-inducing protein structure induced long-lasting protective immunity. This is the first time association between two different secondary structures associated with a specific immunological function has been described: full, long-lasting protective immunity.

publication date

  • 2018/4/6

edition

  • 6

keywords

  • association
  • beta
  • immunity
  • longlasting
  • protective
  • structures

International Standard Serial Number (ISSN)

  • 2296-2646

number of pages

  • 10

start page

  • 106