Neighboring gene regulation by antisense long Non-Coding RNAs Review


  • © 2015 by the authors; licensee MDPI, Basel, Switzerland.Antisense transcription, considered until recently as transcriptional noise, is a very common phenomenon in human and eukaryotic transcriptomes, operating in two ways based on whether the antisense RNA acts in cis or in trans. This process can generate long non-coding RNAs (lncRNAs), one of the most diverse classes of cellular transcripts, which have demonstrated multifunctional roles in fundamental biological processes, including embryonic pluripotency, differentiation and development. Antisense lncRNAs have been shown to control nearly every level of gene regulation—pretranscriptional, transcriptional and posttranscriptional—through DNA–RNA, RNA–RNA or protein–RNA interactions. This review is centered on functional studies of antisense lncRNA-mediated regulation of neighboring gene expression. Specifically, it addresses how these transcripts interact with other biological molecules, nucleic acids and proteins, to regulate gene expression through chromatin remodeling at the pretranscriptional level and modulation of transcriptional and post-transcriptional processes by altering the sense mRNA structure or the cellular compartmental distribution, either in the nucleus or the cytoplasm.

publication date

  • 2015/2/3


  • Antisense RNA
  • Biological Phenomena
  • Cellular Structures
  • Chromatin
  • Chromatin Assembly and Disassembly
  • Cytoplasm
  • DNA
  • Gene Expression
  • Gene Expression Regulation
  • Gene expression
  • Genes
  • Long Noncoding RNA
  • Messenger RNA
  • Modulation
  • Molecules
  • Noise
  • Nucleic Acids
  • Nucleic acids
  • Proteins
  • RNA
  • Switzerland
  • Transcription
  • Transcriptome
  • chromatin
  • cytoplasm
  • deoxyribonucleic acid
  • gene expression
  • interactions
  • modulation
  • molecules
  • nuclei
  • nucleic acids
  • proteins

International Standard Serial Number (ISSN)

  • 1661-6596

number of pages

  • 16

start page

  • 3251

end page

  • 3266