Introduction: Rehabilitation and labor reincorporation in people suffering from mental illness is a fundamental issue to improve the quality of life of affected people, who face significant barriers to find or keep a job, which is why it is necessary to examine the strategies and interventions used in such processes. Objective: To analyze the existing scientific evidence to identify the practices and strategies for rehabilitation and reincorporation into the labor market of workers with mental pathologies. Methodology: A detailed literature search was carried out in scientific databases such as BMC, LANCET, PUBMED, SPRINGER, PSICODOC, SCIELO, focusing on articles in Spanish and English, over a period of ten years. The variables in this review included sociodemographic characteristics, presence of mental illness, interventions used for rehabilitation and return to work, effectiveness of these interventions, obstacles and facilitators for rehabilitation and return to work. Results: Sociodemographic and clinical factors such as women's vulnerability and the prevalence of depressive and anxiety disorders are highlighted. Findings emphasize the importance of social support strategies, workplace accommodations, and psychoeducation programs. Effective approaches such as supported employment and interventions focused on individual needs are identified, although there are differences in the implementation of these strategies. Conclusions: Having a personalized and collaborative approach between health, employment and public policy is key to successful rehabilitation and reemployment. Inclusive strategies and stigma reduction must be integrated to improve worker well-being and organizational productivity.