This monograph explores the challenges and opportunities associated with implementing Smart Contracts in real estate transactions, focusing particularly on the hurdles posed by centralized structures. It provides a comprehensive overview of Smart Contracts, detailing their definition, configuration, and integration with Blockchain technology, which enhances transparency and security in transactions. The study also examines the international regulatory framework relevant to Smart Contracts in real estate, emphasizing the importance of the lex rei sitae principle and various United Nations conventions. The legal foundations for applying Smart Contracts are analyzed, grounded in principles such as contractual freedom and technological neutrality, alongside Civil Law elements of validity, including capacity, object, cause, and consent. The monograph concludes that while Smart Contracts can significantly improve efficiency, security, and transparency in real estate transactions, these benefits can only be fully realized by addressing the accompanying legal and technical challenges comprehensively.