A histoplasma capsulatum-specific IgG1 isotype monoclonal antibody, H1C, to a 70-kilodalton cell surface protein is not protective in murine histoplasmosis Academic Article

journal

  • Clinical and Vaccine Immunology

abstract

  • Monoclonal antibodies to Histoplasma capsulatum can modify pathogenesis. We now show that monoclonal antibody H1C to a 70-kDa antigen increases intracellular fungal growth and reduces macrophage nitric oxide release but has no effect on fungal burden or survival in murine infection. This further demonstrates the complexities of host-pathogen interactions.

publication date

  • 2010-7-1

edition

  • 17

keywords

  • Antigens
  • Growth
  • Histoplasma
  • Histoplasmosis
  • Host-Pathogen Interactions
  • Immunoglobulin G
  • Infection
  • Macrophages
  • Membrane Proteins
  • Monoclonal Antibodies
  • Nitric Oxide
  • Pathogens

International Standard Serial Number (ISSN)

  • 1556-6811

number of pages

  • 4

start page

  • 1155

end page

  • 1158