Background: Ocular inflammatory events following COVID-19 vaccination have been reported in the adult population. Methods: Multinational case series of patients under the age of 18 diagnosed with ocular inflammatory events within 28 days of COVID-19 vaccination. Results: Twenty individuals were included. The most common event was anterior uveitis (n = 8, 40.0percent-flag-change), followed by intermediate uveitis (7 patients, 35percent-flag-change), panuveitis (4 patients, 20percent-flag-change), and posterior uveitis (1 patient, 5percent-flag-change). The event was noticed in the first week after vaccination in 11 patients (55.0percent-flag-change). Twelve patients (60.0percent-flag-change) had a previous history of intraocular inflammatory event. Patients were managed with topical corticosteroids (n = 19, 95.0percent-flag-change), oral corticosteroids (n = 10, 50.0percent-flag-change), or increased dose of immunosuppressive treatment (n = 6, 30.0percent-flag-change). Thirteen patients (65.0percent-flag-change) had a complete resolution of the ocular event without complications. All patients had a final visual acuity unaffected or less than three lines of loss. Conclusion: Ocular inflammatory events may happen in the paediatric population following COVID-19 vaccination. Most events were successfully treated, and all showed a good visual outcome.
