Phylogenetic reconstruction based on Cytochrome b (Cytb) gene sequences reveals distinct genotypes within Colombian Trypanosoma cruzi I populations Academic Article

journal

  • Acta Tropica

abstract

  • Chagas disease caused by Trypanosoma cruzi comprises an important problem of public health in the Americas. This parasite has been recently divided into six Discrete Typing Units (DTUs) due to its high genetic diversity. We sequenced the Cytochorme b (Cytb) gene of 70 T. cruzi I Colombian clones finding four genotypes related to transmission cycles of Chagas disease in Colombia and also to specific hosts of T. cruzi. The genotypes herein described based on Cytb gene sequences are in accordance with those found using the mini-exon gene and reveals once again the enormous genetic diversity at sub-DTU level evidenced in T. cruzi I.

publication date

  • 2011-7-1

edition

  • 119

keywords

  • Chagas Disease
  • Chagas disease
  • Clone Cells
  • Colombia
  • Cytochromes b
  • Exons
  • Genes
  • Genetic Variation
  • Genotype
  • Parasites
  • Population
  • Public Health
  • Trypanosoma cruzi
  • clones
  • cytochrome b
  • exons
  • genes
  • genetic variation
  • genotype
  • nucleotide sequences
  • parasites
  • phylogeny
  • public health

International Standard Serial Number (ISSN)

  • 0001-706X

number of pages

  • 5

start page

  • 61

end page

  • 65