Nuevos datos estadísticos genético-poblacionales para microsatélites en Colombia Thesis

short description

  • Master's thesis

Thesis author

  • Galeano Molina, María Del Socorro

external tutor

  • Alape Ariza, Joseph
  • Siza, Luz Myriam

abstract

  • Since 1990, microsatellites have been used, also known as short tándem repeats (STRs), wich are short DNA sequences consisting of a main motif. In addition to being widely used in the determination of filiation, STRs have been used in evolution and ancestry studies, since they present a high degree of polymorphism, ease of amplification and analysis. The present work deals with the study of microsatellites of the type of short tandem repeats (STRs) in the Colombian population. The objective of this study is to establish new population and forensic statistical parameters analyzing the Colombian population globally, by regions and by departments in a sample of 14. 099 individuals in total, 9. 610 individuals in the parental line, who belong to 21 departments (Antioquia, Atlántico, Bolívar, Boyacá, Caldas, Cauca, Cesar, Choco, Cordoba, Cundinamarca, Huila, La Guajira, Magdalena Nariño, Norte de Santander, Quindío, Risaralda, Santander, Sucre, Tolima and Valle del Cauca), four regions of the country (Caribbean, Pacific, Andina and the Orinoquia and Amazonia) and Bogotá. As a novel finding, the new alleles found are reported and it will be determined if there is population stratification in the Colombian population. With this work we want to provide a database of national coverage, complete and updated, information is provided for 23 microsatellites including the 20 loci of CODIS, as well as Penta D, Penta E and SE 33.

publication date

  • August 21, 2019 8:29 PM

keywords

  • Colombia
  • forensic
  • microsatellites
  • new alleles
  • statistical parameter

Document Id

  • 5a0f7aca-0cb0-48da-a373-cefbe6295199