Introduction: The third cause of death is gynecological ovarian cancer (OC), early detection is key to reducing mortality. The aim is to establish an association between senescence in tissue culture epithelial ovarian cancer (ESO) using enzyme expression ßgalactosidasa / standardized and recognized risk factors for OC. Methods: Descriptive observational exploratory phase of data provided by TRF2 second phase, displays 29 tissues of women with oophorectomy benign conditions, analyzed statistically with 95% confidence, SPSS software version 17, data are presented with standard deviation, average, medium (cell growth rate and ßgal / Standard) and percentages (categorical variables). On comparison with t-student, test for normality with Shapiro Wilks and association by multivariate analysis. Results: Find statistically significant evidence (p <0.05) for association between family history of other cancers with gastric cancer (95% CI -2.84, -0.23) and breast cancer (95% CI: -3 , 39, -0.38); not have health scheme membership (linked) (95% CI -3.67 -0.014), use of barrier contraceptive method (95% CI -3.95, -0.07 ) consumption of sausage (95% CI: -3.30, -0.21) and canned (95% CI -3.62, -0.030) 1 to 3 times per week and alcohol consumption (95% CI: -2, 33, -0.33) with increased expression ßgal / Standard. Discussion: Senescence is antitumorigénica at early ages, is in advanced protumorigénica, when a lot of accumulation of senescent cells in tissue, they change their profile senector producing substances that affect the neighbors, leading to malignant transformation. This research is novel.
