Introduction: In all the countries of the world there is a necessity of having more precise and opportune epidemiological information about psychoactive substances, starting with the scientific knowledge of why some people abuse these substances and some don’t. The objective of this investigation is to establish a epidemiological profile of the patients that use psychoactive substances and that have use the toxicology services of Colsubsidio during the years 2011 and 2012. Also to characterize their population, to identify the consume pattern and their tendencies to be able to create strategies directed toward attention and prevention.Methodology: Descriptive observational exploratory and retrospective study.610 clinical cases were analyzed for clinical and epidemiological variables, thought out univariate analysis according to the type of variable and exploratory bivariate analysis in which proportions were compare.Results: There were a total of 610 patients, 475 men and 135 women. The average age, the medium and the style was 24,9,17 and 16 years old respectively; the majority were single and in high school. The majority of patients under 18 were remitted by ICBF and psychiatry. The abuse and dependence patterns represent the highest percentages. The most consume substances were marihuana, ethanol and tobacco. The treatment for 44.3% of the patients was evaluation per specialty, followed by basic (33.1%) and only (1.1%) went to the consumption prevention of psychoactive substances.Discussion: There is a necessity to lead efforts and resources for the creation of campaigns for early diagnosis and prevention of the consumption ofpsychoactive substances, primarily for the adolescence population.