Purpose: To describe the clinical presentation of Vogt-Koyanagi-Harada syndrome in a group of patients in Colombia.Methods: Retrospective-review of 2638 medical-records of patients with uveitis in two centers during 17 years. Patients with Vogt-Koyanagi-Harada syndrome were gathered to characterize demographic and clinical data. Results: Twenty-five patients with uveitis were diagnosed with Vogt-Koyanagi-Harada syndrome (0.95%), 78.3% females, mean age of diagnosis 37 years old (SD ±29). Twenty-three patients with complete data were included. Main complaints: blurred vision (87%), headaches (47.8%), tinnitus (26.1%) and hearing impairments (21.7%). Ophthalmic findings: bilateral serous retinal-detachment (67.4%), non-granulomatous uveitis (52.3%). Most of the patients were diagnosed with probable disease (56.5%). Mean duration of follow-up was fourteen months; disease relapse was encountered in 26% of patients despite treatment. Conclusion: Patients in Colombia with Vogt-Koyanagi-Harada had clinical features similar to those reported in other Hispanic populations, except for the non-granulomatous uveitis. This disease may be considered as having variation of clinical manifestations across population groups.