Influencia del polimorfismo rs11549465 de HIF-1Α en los niveles de hemoglobina y lactato en pacientes de cirugía cardiovascular Academic Article


  • Revista Facultad de Medicina


  • Introduction: Perioperative anemia is a common complication of cardiovascular surgery. Patients who present the T allele of the HIF-1Α rs11549465 polymorphism may have altered hemoglobin and lactate levels before, during and after surgery, compared to the wild-type allele, due to an increased stability of HIF-1 Α caused by this allele. Objective: To describe the frequency of the T allele in patients scheduled for cardiovascular surgery, and its relationship with hemoglobin and lactate levels. Materials and methods: DNA was isolated from 84 cardiovascular surgery patients for genotyping by Sanger sequencing. Demographic and clinical characteristics were collected. Results: The frequency of the T allele was 0.066 (95percent-flag-changeCI: 0.037-0.114). No significant differences were observed in preoperative, intraoperative, and postoperative hemoglobin and lactate levels between patients with the T allele and those with the wild-type allele. Conclusion: The frequency of the T allele is lower than expected according to other studies in healthy volunteers. No significant differences were observed in some Asian populations, nor in a group of acute myocardial infarction patients. Apparently, rs11549465 genotyping in cardiovascular surgery patients is not a valid risk stratification method for anemia in this group.

publication date

  • 2017-1-1


  • 65


  • Alleles
  • Anemia
  • DNA
  • Demography
  • Gene Frequency
  • Healthy Volunteers
  • Hemoglobins
  • Lactic Acid
  • Myocardial Infarction
  • Population

International Standard Serial Number (ISSN)

  • 0120-0011

number of pages

  • 8

start page

  • 253

end page

  • 260