Toxicidad neurológica asociada a la fenitoína en un paciente metabolizador intermedio para la enzima CYP2C19: Neurological toxicity associated with phenytoin in an intermediate metabolizer patient for CYP2C9 enzyme Academic Article


  • Phenytoin is one of the most used antiepileptics because of its great utility fordifferent types of crisis and low cost. However, its use is limited because the adverseeffects, particularly those that affect the central nervous system. This case shows asuccessful pharmaceutical intervention based on pharmacogenetics, to optimizepharmacotherapy with phenytoin in an intermediate metabolizer patient with clearsigns of neurotoxicity for this drug.

publication date

  • 2018/1/1


  • 20


  • cost
  • metabolizer
  • phenytoin

International Standard Serial Number (ISSN)

  • 1139-6202

number of pages

  • 235

start page

  • 228